Enna Kros’ main damage comes from Omega God, so your number 1 priority is to maintain this buff as doing so will ensure Omega God comes out with full BRV (as opposed to entering with only iBRV) for a huge big hit and more momentum if you throw support their way. You can increase her overhead either through her EX or through her LD. If her EX is not up, you want to check her buffs. If Close Enough Creator or her debuff, Probably Divine Punishment are falling off, use her S1, Kinda Sorta Holy. Otherwise, use her S2, Bold Maneuver.
Kinda Sorta Holy grants Enna Kros her Close Enough Creator buff and inflicts Probably Divine Punishment on all enemies. Close Enough Creator grants strong stat and HP damage boosts to Enna Kross and also rounds her BRV to the nearest thousand and the end of every turn. She also gains a 20% chance to completely fill her EX gauge at the end of her turn. Probably Divine Punishment reduces the enemy’s defense and inflicts Dark and Holy Resist Down.
Bold Maneuver is Enna Kros’s go to move when not refreshing buffs or using her EX. This summons Omega God to attack the enemy. Omega God has stats based on Enna Kros’s but much higher, allowing for more damage.
Atomic Impact is Enna Kros’s slow charging EX, typically taking at least 3 skill uses to fill. Atomic Impact also has a low turn rate, delaying Enna Kros somewhat upon use. Like Bold Maneuver, this summons Omega God to attack, dealing high damage. This will also delete all target’s next turns and grants 2 stacks of Omega God Manifest. This overhead can have up to 6 stacks, each stack allowing Omega God to attack. Once Omega God is summoned, the stack is reduced by 1. This will also set Omega God's cBRV to mBRV whenever she uses Bold Maneuver, Atomic Impact, or Starcrush Slash.
Astral Annihilation is Enna Kros’s LD. This very strong attack summons Omega God to deal high damage to a single target and increases her stacks of Manifest Omega God by 2 and grants Kinda Sorta the Creator. This is best used when Manifest Omega God is nearly out of stacks, to refresh Close-Enough Creator and when Enna Kros’s EX is not charged.